Ismail Es BSc, MSc, PhD

Ismail Eş holds a B.Sc. in bioengineering with an M.Sc. degree in genetics and molecular biology. He obtained his PhD in chemical engineering from the University of Campinas. His research has covered diverse areas, including microfluidics, biopolymers, nanotechnology, and gene/drug delivery. He has worked as an honorary research associate at the UCL Biochemical Engineering Department, concentrating on tumor-on-a-chip models, and as a post-doc at the UCL School of Pharmacy, where he developed microfluidic systems for AAV vector production. At the National Nanotechnology Research Center of Turkey, his work encompassed microfluidics, microneedles, biopolymers, and spheroids. Currently, he is engaged in wearable and implantable electronic devices at the University of Oxford, Institute of Biomedical Engineering.

• Manufacturing techniques
• Microfabrication
• Microfluidics
• Microneedles
• Smart materials
• Biopolymers
• Lab-on-a-chip
• Organ-on-a-chip
• Drug delivery
• Gene delivery
• Wearable devices
• Implantable devices

Research Articles

• EŞ, I., Kafadenk, A., Inci, F., 2023. A high-precision method for manufacturing tunable solid microneedles using dicing saw and xenon difluoride-induced dry etching. JOURNAL OF MATERIALS PROCESSING TECHNOLOGY.
• EŞ, I., Kafadenk, A., Gormus, B. and Inci, F., 2023. Xenon Difluoride dry etching for the microfabrication of solid microneedles as a potential strategy in transdermal drug delivery. SMALL 2206510.
• Erdem, Ö., EŞ, I., Saylan, Y., Atabay, M., Gungen, M.A., Ölmez, K., Denizli, A. and Inci, F., 2023. In situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system. NATURE COMMUNICATIONS, 14(1), p.4840.
• EŞ, I., Malfatti-Gasperini, A.A. and de la Torre, L.G., 2022. The diffusion-driven microfluidic process to manufacture lipid-based nanotherapeutics with stealth properties for siRNA delivery. COLLOIDS AND SURFACES B: BIOINTERFACES, 215, p.112476 (FRONT COVER).
• EŞ, I., Montebugnoli, L.J., Filippi, M.F.P., Malfatti-Gasperini, A.A., Radaic, A., de Jesus, M.B. and de la Torre, L.G., 2020. High-throughput conventional and stealth cationic liposome synthesis using a chaotic advection-based microfluidic device combined with a centrifugal vacuum concentrator. CHEMICAL ENGINEERING JOURNAL, 382, p.122821.
• Barati, M., Javanmardi, F., Jabbari, M., Mokari-Yamchi, A., Farahmand, F., EŞ, I., Farhadnejad, H., Davoodi, S.H. and Khaneghah, A.M., 2020. An in silico model to predict and estimate digestion-resistant and bioactive peptide content of dairy products: A primarily study of a time-saving and affordable method for practical research purposes. LWT, 130, p.109616.
• Gahruie, H.H., Niakousari, M., Parastouei, K., Mokhtarian, M., EŞ, I. and Mousavi Khaneghah, A., 2020. Co‐encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 44(8), p.e14629.
• Yekta, M.M., Rezaei, M., Nouri, L., Azizi, M.H., Jabbari, M., EŞ, I. and Khaneghah, A.M., 2020. Antimicrobial and antioxidant properties of burgers with quinoa peptide‐loaded nanoliposomes. JOURNAL OF FOOD SAFETY, 40(2), p.e12753.
• Azari, A., Mahmoudian, M.H., Niari, M.H., EŞ, I., Dehganifard, E., Kiani, A., Javid, A., Azari, H., Fakhri, Y. and Khaneghah, A.M., 2019. Rapid and efficient ultrasonic assisted adsorption of diethyl phthalate onto FeIIFe2IIIO4@ GO ANN-GA and RSM-DF modeling, isotherm, kinetic and mechanism study. MICROCHEMICAL JOURNAL, 150, p.104144.
• Moazzen, M., Khaneghah, A.M., Shariatifar, N., Ahmadloo, M., EŞ, I., Baghani, A.N., Yousefinejad, S., Alimohammadi, M., Azari, A., Dobaradaran, S., Rastkari, N., Nazmara, S., Delikhoon, M., and Khaniki, GJ., 2019. Multi-walled carbon nanotubes modified with iron oxide and silver nanoparticles (MWCNT-Fe3O4/Ag) as a novel adsorbent for determining PAEs in carbonated soft drinks using magnetic SPE-GC/MS method. ARABIAN JOURNAL OF CHEMISTRY, 12(4), pp.476-488.
• EŞ, I., Ok, M.T., Puentes-Martinez, X.E., de Toledo, M.A.S., de Pinho Favaro, M.T., Cavalcanti, L.P., Cassago, A., Portugal, R.V., Azzoni, A.R. and de la Torre, L.G., 2018. Evaluation of siRNA and cationic liposomes complexes as a model for in vitro siRNA delivery to cancer cells. COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 555, pp.280-289.
• Hashemi, S.M.B., Mousavi Khaneghah, A., Kontominas, M.G., EŞ, I., Sant’Ana, A.S., Martinez, R.R. and Drider, D., 2017. Fermentation of sarshir (kaymak) by lactic acid bacteria: antibacterial activity, antioxidant properties, lipid and protein oxidation and fatty acid profile. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 97(13), pp.4595-4603.
• Hashemi, S.M.B., Khaneghah, A.M., Ghahfarrokhi, M.G. and EŞ, I., Basil-seed gum containing Origanum vulgare subsp. viride essential oil as edible coating for fresh cut apricots. POSTHARVEST BIOLOGY AND TECHNOLOGY, 125, pp.26-34.
• EŞ, I., Ribeiro, M.C., dos Santos Júnior, S.R., Khaneghah, A.M., Rodriguez, A.G. and Amaral, A.C., 2016. Production of cyclodextrin glycosyltransferase by immobilized Bacillus sp. on chitosan matrix. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 39(10), pp.1487-1500.

Review Articles

• EŞ, I, Khaneghah, A.M., 2023. Advancing Food Quality Assurance: Integrating Microneedle Technology with Advanced Analytical Methods. NANO TODAY.
• Mariello, M., EŞ, I., and Proctor, C.M., 2023. Soft and flexible bioelectronic micro-systems for electronically controlled drug delivery. ADVANCED HEALTHCARE MATERIALS (Invited review), 2302969.
• Ece, E., EŞ, I. (Corresponding author)* and Inci, F., 2023. Microneedle technology as a new standpoint in agriculture: Treatment and sensing. MATERIALS TODAY.
• Yilmaz, E., Ece, E., Erdem, O., EŞ,, Inci, F., 2023. A sustainable solution to skin diseases: Eco-friendly transdermal patches. PHARMACEUTICS, 5(2), p.579. (Invited Review).
• Sagdic, K., EŞ, I., Sitti, M. and Inci, F., 2022. Smart materials: rational design in biosystems via artificial intelligence. TRENDS IN BIOTECHNOLOGY, 40(8), p.987-1003. (Invited Review, Front Cover).
• Erdem, O., EŞ̧, I., Saylan, Y. and Inci, F., 2021. Unifying the efforts of medicine, chemistry, and engineering in biosensing technologies to tackle the challenges of the COVID-19 pandemic. ANALYTICAL CHEMISTRY, 94(1), pp.3-25 (Front Cover).
• Erdem, Ö., EŞ, I., Akceoglu, G.A., Saylan, Y. and Inci, F., 2021. Recent advances in microneedle-based sensors for sampling, diagnosis and monitoring of chronic diseases. BIOSENSORS, 11(9), p.296.
• Khaneghah, A.M., Abhari, K., EŞ, I., Soares, M.B., Oliveira, R.B., Hosseini, H., Rezaei, M., Balthazar, C.F., Silva, R., Cruz, A.G. and Ranadheera, C.S., 2020. Interactions between probiotics and pathogenic microorganisms in hosts and foods: A review. TRENDS IN FOOD SCIENCE & TECHNOLOGY, 95, pp.205-218.
• EŞ, I., Gavahian, M., Marti-Quijal, F.J., Lorenzo, J.M., Khaneghah, A.M., Tsatsanis, C., Kampranis, S.C. and Barba, F.J., 2019. The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges. BIOTECHNOLOGY ADVANCES, 37(3), pp.410-421.
• EŞ, I., Kamani, M.H., Lorenzo, J.M., Remize, F., Roselló-Soto, E., Barba, F.J., Clark, J. and Khaneghah, A.M., 2019. Advances in plant materials, food by-products, and algae conversion into biofuels: use of environmentally friendly technologies. GREEN CHEMISTRY, 21(12), pp.3213-3231.
• Gavahian, M., Munekata, P.E., EŞ, I., Lorenzo, J.M., Khaneghah, A.M. and Barba, F.J., 2019. Emerging techniques in bioethanol production: from distillation to waste valorization. GREEN CHEMISTRY, 21(6), pp.1171-1185.
• Lorenzo, J.M., Mousavi Khaneghah, A., Gavahian, M., Marszałek, K., EŞ, I., Munekata, P.E., Ferreira, I.C. and Barba, F.J., 2019. Understanding the potential benefits of thyme and its derived products for food industry and consumer health: From extraction of value-added compounds to the evaluation of bioaccessibility, bioavailability, anti-inflammatory, and antimicrobial activities. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 59(18), pp.2879-2895.
• Coppa, C.F.S.C., Khaneghah, A.M., Alvito, P., Assunção, R., Martins, C., EŞ, I., Gonçalves, B.L., de Neeff, D.V., Sant’Ana, A.S., Corassin, C.H. and Oliveira, C.A.F., 2019. The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: A review. TRENDS IN FOOD SCIENCE & TECHNOLOGY, 92, pp.81-93.
• Barba, F.J., Gavahian, M., EŞ, I., Zhu, Z., Chemat, F., Lorenzo, J.M. and Khaneghah, A.M., 2019. Solar radiation as a prospective energy source for green and economic processes in the food industry: From waste biomass valorization to dehydration, cooking, and baking. JOURNAL OF CLEANER PRODUCTION, 220, pp.1121-1130.
• Mousavi Khaneghah, A., EŞ, I., Raeisi, S. and Fakhri, Y., 2018. Aflatoxins in cereals: State of the art. JOURNAL OF FOOD SAFETY, 38(6), p.e12532.
• Mousavi Khaneghah, A.M.I.N., Hashemi, S.M.B., EŞ, I., Fracassetti, D. and Limbo, S., 2018. Efficacy of antimicrobial agents for food contact applications: biological activity, incorporation into packaging, and assessment methods: a review. JOURNAL OF FOOD PROTECTION, 81(7), pp.1142-1156.
• EŞ, I., Khaneghah, A.M., Barba, F.J., Saraiva, J.A., Sant’Ana, A.S. and Hashemi, S.M.B., 2018. Recent advancements in lactic acid production-a review. FOOD RESEARCH INTERNATIONAL, 107, pp.763-770.
• EŞ, I., Khaneghah, A.M., Hashemi, S.M.B. and Koubaa, M., 2017. Current advances in biological production of propionic acid. BIOTECHNOLOGY LETTERS, 39(5), pp.635-645.
• EŞ, I., Vieira, J.D.G. and Amaral, A.C., 2015. Principles, techniques, and applications of biocatalyst immobilization for industrial application. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 99(5), pp.2065-2082.

Book Chapters

• EŞ, I., Haciosmanoğlu, N., Ece, E., Gulgen, M., and Inci, F., 2023. Machine learning-integrated systems for organ-on-chips devices, In: Smart organ-on-chip devices, Stimuli active microfluidic platforms for dynamic cell culture. ELSEVIER (IN PREPARATION).
• De la Torre, L.G., Pessoa, A.C.S.N., Carvalho, B.G.D., Taketa, T.B., EŞ, I. and Perli, G., 2021. Bulk and Microfluidic Synthesis of Stealth and Cationic Liposomes for Gene Delivery Applications. In DNA Vaccines (pp. 253-269). SPRINGER, HUMANA, NEW YORK.
• De la Torre, L.G., Sipoli, C.C., Oliveira, A.F., EŞ, I., Pessoa, A.C., Vitor, M.T., Vit, F.F. and Naves, T.F., 2017. Biopolymers for gene delivery applications. In Biopolymer-Based Composites, Drug Delivery and Biomedical Applications, (pp. 289-323). WOODHEAD PUBLISHING.
• EŞ, I., Khaneghah, A.M. and Akbariirad, H., 2017. Global regulation of essential oils. Essential oils in food processing: chemistry, safety and applications, pp.327-338, WILEY.
• Mousavi Khaneghah, S. M. B. Hashemi, EŞ, I., A. Gholamhosseinpour, M. R. Loizzo, A. Giardinieri, D. Pacetti, K. Pourmohammadi, D. S. Ferreira, in Innov. Therm. Non-Thermal Process. Bioaccessibility Bioavailab. Nutr. Bioact. Compd. (Eds.: F. J. Barba, J. M. A. Saraiva, G. Cravotto, J. M. Lorenzo), WOODHEAD PUBLISHING, 2019, pp. 241–266.
• M. B. Hashemi, K. Pourmohammadi, A. Gholamhosseinpour, EŞ, I., D. S. Ferreira, A. Mousavi Khaneghah, in Innov. Therm. Non-Thermal Process. Bioaccessibility Bioavailab. Nutr. Bioact. Compd. (Eds.: F. J. Barba, J. M. A. Saraiva, G. Cravotto, J. M. Lorenzo), WOODHEAD PUBLISHING, 2019, pp. 267–289.

Patent Applications

• Inventors: Ismail EŞ, Leonardo Jose Montebugnoli, Allan Radaic, Marcelo Bispo de Jesus, Lucimara Gaziola de la Torre, Patent name: Microfluidic process for obtaining stealth cationic liposomes (2020/6) (Patent number: WO2020107088).
• Inventors: Ismail EŞ, Abdullah Kafadenk, Fatih Inci, Patent name: Xenon difluoride dry etching process optimization for solid microneedle synthesis, PCT/TR2023/050,917, Turkish Patent and Trademark Office.
• Inventors: Ismail EŞ, Abdullah Kafadenk, Fatih Inci, Patent name: Rapid cleanroom-free manufacturing of solid microneedles using dicing saw combined with dry etching PCT/TR2023/051,315, Turkish Patent and Trademark Office.
• Inventors: Özgecan Erdem, Ismail EŞ, Fatih Inci, Patent name: Microfluidic synthesis of Molecularly Imprinted Polymeric nanoparticle synthesis for biosensor application, PCT/TR2023/050,924, Turkish Patent and Trademark Office.