Dr

Wahbi K. El-Bouri DPhil (Oxon) MEng

Postdoctoral Research Assistant in Cerebral Blood Flow Modelling

Research Fellow and Tutor, Keble College

  • Biography
  • Research
  • Publications

Biography

Dr. Wahbi El-Bouri is a postdoctoral research assistant in the Cerebral Hemodynamics Group at the University of Oxford with Professor Stephen Payne.

His DPhil (PhD) thesis was in the realm of cerebral blood flow modelling, in particular with regards to drawing a link between the 'unseen', and hence clinically unmeasurable microcirculation, and the clinically measurable parameters from techniques such as MRI. His attempts at plugging this ‘imaging gap’ have continued into his postdoctoral research where he is currently involved in developing in-silico clinical trials of stroke treatment as part of an EU funded Horizon 2020 project, as well as working on methods to measure intracranial pressure non-invasively, and working on understanding the microvascular role in dementia and cognitive decline.

Outside of research Wahbi teaches undergraduate engineering at Keble college, enjoys playing football, and writes short stories in his spare time.

ORCID ID
Google Scholar

News

See here for an article Wahbi wrote on his research.

Research Interests

Wahbi's research interests are primarily related to the brain. In particular, how does the microcirculation affect blood and oxygen transport in the brain? What happens when things go wrong? Can we link what we can measure in humans e.g. MRI scans (the macro-scale) to what we cannot see (the capillaries – the micro-scale) in order to help us better understand the mechanisms of disease? These are just some of the questions Wahbi tries to answer in his research. As engineers, we are ideally positioned to use our creative problem-solving skills to tackle these sorts of interdisciplinary problems.

Wahbi currently has three main research projects/interests revolving around stroke and stroke treatment, measuring intracranial pressure non-invasively, and dementia and cognitive decline.

Current Projects

  • INSIST (In-Silico Trials for Treatment of Acute Ischemic Stroke)  Part of an EU funded Horizon 2020 project where multi-scale models of blood flow and oxygen transport in human brains are being developed to simulate stroke and stroke treatment.
  • Measuring Intracranial Pressure Non-Invasively  In collaboration with Southampton General Hospital, non-invasive measures of intracranial pressure are being developed, in particular via the tympanic membrane displacement in the ear.
  • Dementia and Cognitive Decline  Microvascular models are being developed to elucidate changes that occur with age, and the potential impact these changes have on cognitive ability.

Research Groups

Related Academics

Publications

  • Multi-scale homogenization of blood flow in 3-dimensional human cerebral microvascular networks, WK El-Bouri, SJ Payne, Journal of theoretical biology 380, 40-47
  • Screening cultures for detection of methicillin-resistant Staphylococcus aureus in a population at high risk for MRSA colonisation: identification of optimal combinations of anatomical sites, K El-Bouri, W El-Bouri, Libyan Journal of Medicine 8 (1), 22755
  • A statistical model of the penetrating arterioles and venules in the human cerebral cortex, WK El‐Bouri, SJ Payne, Microcirculation 23 (7), 580-590
  • Investigating the effects of a penetrating vessel occlusion with a multi-scale microvasculature model of the human cerebral cortex, WK El-Bouri, SJ Payne, NeuroImage 172, 94-106
  • Multi-scale homogenization of the mass transport equation in periodic capillary networks, WK El-Bouri, SJ Payne, Proceedings of the 4th international conference on computational & mathematical biomedical engineering, p.178-181
  • Multi-scale modelling of the microvasculature in the human cerebral cortex, WK El-Bouri, University of Oxford
  • Dynamic Changes in Microvascular Flow Conductivity and Perfusion After Myocardial Infarction Shown by Image‐Based Modeling, P Gkontra, WK El‐Bouri, KA Norton, A Santos, AS Popel, SJ Payne, AG Arroyo, Journal of the American Heart Association 8 (7), e011058
  • Quantifying the contribution of intracranial pressure and arterial blood pressure to spontaneous tympanic membrane displacement, WK El-Bouri, D Vignali, K Iliadi, D Bulters, RJ Marchbanks, AA Birch, DM Simpson, Physiological measurement 39 (8), 085002
  • Modelling dynamic changes in blood flow and volume in the cerebral vasculature, SJ Payne, WK El-Bouri, NeuroImage 176, 124-137
  • Linking macro-scale voxel behaviour to the microvasculature using a multi-scale model, WK El-Bouri, SJ Payne, Journal Of Cerebral Blood Flow and Metabolism 37, 422-423