Dr

Timothee Baudequin

Post-doctoral Research Assistant

  • Biography
  • Research
  • Publications

Education

2015 - PhD

Université de Technologie de Compiègne (UTC, France), Biomechanics and Bioengineering Laboratory (UMR CNRS 7338 BMBI).

  • Biological and mechanical characterization of a biohybrid bone substitute rebuilt in bioreactor for maxillofacial applications.
  • Study of new materials (electrospinning) for bone-to-tendon tissue engineering.
  • Human stem cells/endothelial cells co-culture and mechanical solicitations in situ.

2012 - Master of Science degree in Mechanical Engineering

École Supérieure des Sciences et Technologies de l’Ingénieur de Nancy (ESSTIN, now Polytech Nancy, Lorraine INP, France)

Research Experience

Nov. 2015 – Dec. 2017: Post-doctoral fellow at McGill University (Montréal, Québec, Canada).

Biomat’X laboratory, Pr. Maryam Tabrizian.

  • Injectable chitosan sponges characterization, in vivo and in vitro optimization for bone regeneration applications.
  • Adipose-derived stem cell encapsulation (collaboration with Dr. Hamdy’s lab, Shriners hospital for children) for bone critical size defects.

Feb. 2012 – July 2012: Cell and Tissue Biophysics Imaging Platform

FR3209 CNRS - PTIBC – IBISA, Biopôle, Nancy, France

  • Study of a multiphoton confocal microscopy prototype for the analysis of the mechanical properties of biological tissues.

Awards and Achievements

  • MITACS accelerate program grant (McGill University / Aligo Innovation), 2015-2016.
  • CNRS Fellowship, INSIS Collegium, Compiègne (France), 2012-2015.
  • Best article award, TERMIS-EU SYIS and Mary Ann Liebert, Inc. Publishers, 2017, for Baudequin et al 2015.
  • PhD Award, European Society for Artificial Organs (ESAO), 2016.
  • PhD Award, Prix de Thèse Guy Deniélou, Université de Technologie de Compiègne/Saint-Gobain Sekurit, 2016.
  • yESAO Exchange Award, European Society for Artificial Organs, 2015 (Leibniz Universität Hannover, Germany).

Research Interests

Dr Timothee Baudequin's work bridges mechanical/material engineering and tissue engineering. His research focuses on the development of new biomaterials for in vitro and in vivo cell culture to grow various tissues.

He manages both development and characterization steps and to investigate innovative approaches and applications for such scaffolds, in particular for interfacial tissue engineering. Timothee is specifically curious about their influence on stem cell differentiation, and one of his major interests is to highlight synergistic effects between chemical, biological and mechanical signals on cell development.

Current Research Projects

  • Bioengineering processes for stem cell expansion
  • Design and 3D-printing of bioreactor-based translational solutions
  • Study of polymer beads made of smart biomaterials for non-invasive cell culture

Selected Publications

  • Nguyen L, Odeleye A, Chui CY, Baudequin T, Cui Z, Ye H, Development of thermo-responsive polycaprolactone macrocarriers conjugated with Poly(N-isopropyl acrylamide) for cell culture, in press, 2019, Scientific Reports.
  • Baudequin T, Legallais C, Bedoui F, In vitro bone cell response to tensile mechanical solicitations: is there an optimal protocol?, Biotechnology Journal, 2018, DOI: 10.1002/biot.201800358.
  • Baudequin T and Tabrizian M, Multi-lineage Constructs for Scaffold-based Tissue Engineering: A review of Tissue-Specific Challenges, Advanced Healthcare Materials, 2017 Nov, DOI: 10.1002/adhm.201700734.
  • Baudequin T, Benameur L (equal contribution), Mekhail M, Tabrizian M, The Bioconjugation Mechanism of Purine Cross-linkers Affects Microstructure and Cell Response to Ultra Rapidly Gelling Purine-Chitosan Sponges, Journal of Materials Chemistry B, 2017 Dec, DOI: 10.1039/C7TB02968C.
  • Baudequin T, Gaut L, Mueller M, Huepkes A, Glasmacher B, Duprez D, Bedoui F and Legallais C, The osteogenic and tenogenic differentiation potential of stem cells cultured on PCL/PLA electrospun scaffolds in the absence of specific differentiation medium, Materials (Basel) 10:1387. http://www.mdpi.com/1996-1944/10/12/1387.
  • Baudequin T, Bedoui F, Dufresne M, Paullier P and Legallais C, Towards the development and characterisation of an easy handling sheet-like biohybrid bone substitute, Tissue Eng Part A. 2015 Jun;21(11-12):1895-905. doi: 10.1089/ten.TEA.2014.0580.