Dr.

Michael Gray

Senior Research Fellow in Clinical Therapeutic Ultrasound

  • Biography
  • Research
  • Publications

Biography

Dr. Michael Gray joined the BUBBL group in September 2015 primarily to work on a Phase-1 clinical trial of ultrasound-mediated targeted drug delivery for treatment of liver cancer.

Over the preceding 23 years, he was a research engineer and principal investigator at Georgia Tech, working in research areas including submarine sonar, cetacean soft tissue characterization, photoacoustics, fish hearing, and non-destructive structural evaluation.

Research Interests

Michael's current research areas and interests include clinical translation of cavitation monitoring techniques and the use of sound, magnetism, and light for targeted drug delivery.

Selected Publications

  • Gray, M.D., Lyon, P.C., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., and Coussios, C.C., “Focused ultrasound hyperthermia for targeted drug release from thermosensitive liposomes: results from a Phase 1 Trial”, Radiology (published online 15 Jan. 2019)
  • Mannaris, C., Bau, L., Grundy, M., Gray, M.D., Lea-Banks, H., Seth, A., Teo, B., Carlisle, R., Stride, E., and Coussios, C.C., “Microbubbles, nanodroplets and gas-stabilizing solid particles for ultrasound-medicated extravasation of unencapsulated drugs: an exposure parameter optimization study”, Ultrasound in Medicine and Biology, (published online 14 Jan. 2019)
  • Gray, M.D. and Coussios, C.C., “Broadband ultrasonic attenuation estimation and compensation with passive acoustic mapping”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, (2018) 65(11): 1997-2011
  • Lyka, E., Coviello, C., Paverd, C., Gray, M.D., and Coussios, C.C., “Passive acoustic mapping using data-adaptive beamforming based on higher-orders statistics”, IEEE Transactions on Medical Imaging, (2018) 37(12): 2582-2592
  • Lyon, P.C., Gray, M.D., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., and Coussios, C.C., “TarDox: A Phase I trial investigating the safety and feasibility of ultrasound-triggered targeted drug delivery in liver tumours”, Lancet Oncology (2018) 19(8): 1027-1039
  • Barnsley, L.C., Gray, M.D., Beguin, E., Carugo, D., and Stride, E., “A combined magnetic-acoustic device for simultaneous, co-aligned application of magnetic and ultrasonic fields”, Advanced Materials Technologies, (2018) 3(7): 1800081
  • Gray, M.D., Lyka, E., and Coussios, C.C., “Diffraction effects and compensation in passive acoustic mapping”, IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control (2018) 65(2): 258-268
  • Holguin, S.Y., Gray, M.D., Joseph, P., Thadhani, N., and Prausnitz, M.R., “Photoporation using carbon nanotubes or intracellular delivery of molecules and its relationship to photoacoustic pressure”, Advanced Healthcare Materials (2018) 7(5): 1701007:1-10