Dr

Julian Dye DPhil

Departmental Lecturer

Lecturer, Trinity College

  • Biography
  • Research
  • Publications

Biography

Julian graduated in Biochemistry (St Anne’s College, Oxford) in 1983 and joined the Surgical Unit, St Mary’s Hospital Medical School, London as a biochemist. He then moved to Dept Anatomy & Cell Biology, Imperial College for his PhD in endothelial cell biology, followed by a joint post-doctoral project with St Mary Hospital Medical School, Manchester, studying pre-eclampsia.

He then moved to The RAFT Institute, and established a research programme to develop an angiogenic approach for skin reconstruction. He invented ‘Smart Matrix’ pro-angiogenic synthetic dermal replacement, and led the clinical product development and translation to GMP manufacture. This involved a start-up company, SmartMatrix Ltd, for which he was CSO from 2011-13. He then took a Lecturership at the Open University, and joined the Department's Institute of Biomedical Engineering in 2016.

julian now leads a group developing Bio-Intelligent Biomaterial Scaffolds and clinically relevant, cost-economic biomaterial manufacture processes.

ResearchGate

Lectures

  • Interfacial Chemistry and Applications
  • Tissue Engineering
  • Bioseparation

Awards & Achievements

  • UK lead for 3DMed, an Interreg 2Seas cooperation project

Research Interests

  • Bio-intelligent biomaterial scaffolds
  • Tissue Engineering
  • Regenerative medicine
  • Interfacial engineering
  • 3D-bioprinting

Publications

  • Dye, J.F (2018) From Secondary Intent to Accelerated Regenerative Healing: Emergence of the Bio-intelligent Scaffold Vasculogenic Strategy for Skin Reconstruction. In: Tissue Engineering and Regeneration: Vascularization for Tissue Engineering and Regenerative Medicine. Holnthoner, W, Redl, H., Banfi, A. & Kirkpatrick, J. Springer. (In press).
  • Lim, X, Potter, M, Cui, Z & Dye, JF (2018) Characterization of EmDerm – a novel hierarchically structured bio-intelligent scaffold for tissue regeneration. J Biomaterial Science 29, 79-91.
    Sharma V, Blackwood KA, Haddow D, Hook L, Mason C, Dye JF, Gareta-Garcia E. (2015) Method for estimating protein binding capacity of polymeric systems. Biochemie Open 1 p40-50.
  • Sharma V, Patel, N, Dye, JF, Hook, L, Mason, C, Gareta-Garcia E. (2015) Albumin removal from human fibrinogen preparations for manufacturing human fibrin-based biomaterials. Biochemie Open 1 [6/6/2015] p6-10.
  • Elizabeth Ann Wahl, E.A., Fierro, F., Peavy, T.R., Hopfner, U.,Dye, JF. Machens, HG, Egaña, JT & Schenck T.L. (2014) Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Increase Angiogenesis In Vivo. BioMed Research International. 108571 (9/4/15).
  • Gareta-Garcia, E, Ravindran, N & Dye, J F. (2014) Apoptotic primary normal human dermal fibroblasts for in vitro models of fibrosis. Analytical Biochemistry. doi: http://dx.doi.org/10.1016/j.ab.2014.10.009
  • Tanja Macheiner, T., Anna Kuess, A., Dye, JF., & Saxena, AK. (2014) A novel method for isolation of epithelial cells from ovine esophagus for tissue engineering. Bio-medical materials and engineering. 24(2):1457-1468.
  • Gareta-Garcia, E, Ravindran, N, Sharma, V Samizadeh, S & Dye, J F. (2013) A Novel Multiparameter In Vitro Model of Three-Dimensional Cell Ingress Into Scaffolds for Dermal Reconstruction to Predict In Vivo Outcome. BioResearch Open Access 2 (6) 412-420.
  • Dye, JF (2012) Guest Editorial. A synthetic scaffold to treat full thickness wounds. Wounds International 6 (2), 6-7
  • Caiado, F Carvalho, Fernanda Silva, Catarina Castro, Nuno Clode, J. F. Dye & Sergio Dias (2011). Fibrin E modulates endothelial progenitors adhesion, differentiation and angiogenic growth factor production and promotes wound healing. Biomaterials 32 (29) 7096-105.
  • Egaña JT, Danner S, Kremer M, Rapoport DH, Dye JF, Lavandero S, Kruse C, Machens HG. (2009) Glandular-derived stem cells improve vascularisation in scaffold-mediated dermal regeneration Biomaterials 30(30): 5918-26.
  • Edwards FC., Taheri A., Dann SC. & Dye JF. (2011) Characterisation of cytolytic neutrophil activation in vitro by amorphous hydrated calcium phosphate as a model of biomaterial inflammation. J Biomed Mat Res pt A, 96A (3) 552-565.
  • Bitto, A, Galeano, M, Squadrito, F, Minutoli, L, Polito, F., Dye, JF, Clayton, EA, Calo, M., Ventuti, F, Altavilla, D. (2008) Polydeoxyribonucleotide (PDRN) improves angiogenesis and wound healing in experimental thermal injury. Critical Care Medicine 2008. 36(5): p. 1594-602.
  • Baldwin, C., Potter, M., Clayton, E., Irvine, I. & Dye, JF. (2009) Vacuum assisted closure accelerates the integration of Integra - a suggested mechanism of action. Ann Plast Surg. Jan;62(1):92-6.
  • Potter, M., Banwell, P., Baldwin, C., Clayton, L., Irvine, L, Linge, C., Grobbelaar, A.O, Sanders, R & Dye, JF. (2008). In vitro optimisation of Topical Negative Pressure regimes for angiogenesis into Synthetic Dermal Replacements. Burns. 34(2): 164-174.
  • Potter, M., Linge, C., Cussons, P., Dye, JF., & Sanders, R. (2006) An investigation to optimise angiogenesis within potential dermal replacements. Plas. Recon. Surg. Vol 117 (6), p1876-1885.
  • Dye, JF., Barnett, M., Linge, C. and Sanders, R. (2004) The angiogenic sprouting response to collagen requires src family kinase activity. Proceedings of the 23rd European Conference on Microcirculation, ed. Martins e Silva J., Saldanha C., Oliveira V., Prie A., Shore A. Medimond. Bologna. p87-93.
  • Potter, M, Linge, C, Dye, JF, and Sanders, R. (2004) Fibrin is a potent stimulus of endothelial cell migration. Proceedings of the 23rd European Conference on Microcirculation, ed. Martins e Silva J., Saldanha C., Oliveira V., Prie A., Shore A., Medimond. Bologna. P131-135.
  • Dye, J. F., Laurence, L., L. Leach, L., Linge, C., Firth.J.A. & P. Clark. (2004) Distinct patterns of in vitro angiogenic behaviour of human microvascular endothelial cells is determined by extracellular matrices. Endothelium 11 (3/4) p151-167.
  • Dye, J. F., Vause, S., Johnston, T, Clark, P., Firth, JA., D’Souza, SWS., Sibley, CP. and Glazier, JD. (2004) Characterisation of cationic amino acid transporters and expression of nitric oxide synthase in human placental microvascular endothelial cells. FASEB J. Rapid communication online Nov 2003
  • Leach, L., MO. Babawale, MJ. Lammiman, JF. Dye, P. Clark and JA. Firth (2002) Endothelial phenotype of the materno-fetal barrier. J Anat 200 (5) p531.
  • Dye, J. F., Clark, P., Leach, L., and Firth, J. A. (2001) Cyclic AMP and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro. Microvascular Research. 62 (2), 94-113.
  • Dye, J. F., Jablenska, R., Donnelley, J.L., Lawrence, L., Leach, L., Clark, P., and Firth, J. A. (2001) Phenotype of the endothelium in the human term placenta. Placenta. 22, 32-43.
  • Naresh Kasoju, Linh Nguyen, Julian F Dye, Zhanfeng Cui, Hua Ye (2017) Techniques for Modifying Biomaterials to Improve Hemocompatibility in ‘Hemocompatibility of Biomaterials for Clinical Applications’ ed. Dr. Christopher Siedlecki, Chpt 17. Pub: Elsevier Ltd. Oxford, United Kingdom